Hypoxia-inducible factors: central regulators of the tumor phenotype
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منابع مشابه
Hypoxia-inducible factors: central regulators of the tumor phenotype.
Low oxygen levels are a defining characteristic of solid tumors, and responses to hypoxia contribute substantially to the malignant phenotype. Hypoxia-induced gene transcription promotes characteristic tumor behaviors, including angiogenesis, invasion, metastasis, de-differentiation and enhanced glycolytic metabolism. These effects are mediated, at least in part, by targets of the hypoxia-induc...
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ژورنال
عنوان ژورنال: Current Opinion in Genetics & Development
سال: 2007
ISSN: 0959-437X
DOI: 10.1016/j.gde.2006.12.006